SIO submits letters annually to the NCCN, advocating for important changes and updates to the current treatment guidelines. These efforts are led annually by the NCCN Task Force. Download our recent letters below.
View and download Current NCCN Guidelines
NCCN Soft Tissue Sarcoma Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Soft Tissue Sarcoma Guidelines. Authored by Jack Jennings, MD, PhD, Joseph Erinjeri, MD, PhD, and Daehee Kim, MD, this letter requests two specific changes to the NCCN Soft Tissue Sarcoma Cancer Guidelines: 1) the addition of drug-eluting bead chemoembolization as a treatment option for desmoid tumors and transarterial chemoembolization (TACE) as a treatment option for selective extra-abdominal desmoid tumors; and 2) clarifying embolization procedures to include transarterial bland embolization, chemoembolization, and radioembolization for non-lung metastases treatment.
Download the 2023 Letter
Download the 2022 Letter
NCCN Adult Cancer Pain Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Guidelines of Adult Cancer Pain. Submitted by Jack Jennings, MD, PhD, Associate Professor, Washington University; Anil N. Kurup, MD, Radiologist, Mayo Clinic; and Majid Maybody, MD, Associate Professor of Radiology, Memorial Sloan Kettering Cancer Center. This letter requests the NCCN Adult Cancer Pain Guideline Panel review eight specific changes and data for inclusion in the management of adult cancer pain.
NCCN Bone Cancer Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Bone Cancer Panel. Submitted by John Smirniotopoulos, MD, MS, MedStar Georgetown University Hospital; Neil J. Resnick, MD, UMass Memorial Health; Rahul Sheth, MD, MD Anderson Cancer Center; Ernesto Santos, MD, Memorial Sloan Kettering Cancer Center; Sean Tutton, MD, UCSD Health; Stephen Yevich, MD, MD Anderson Cancer Center; Junjian Huang, MD, Emory University School of Medicine, this letter requests the NCCN Panel to include a section on the Principles of Image-Guided Tumor Ablation, similar to existing sections for Radiation Therapy (BONE-C) and Pathology (BONE-D).
NCCN Breast Cancer Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Guidelines of Breast Cancer. Submitted by Amy Deipolyi, MD, PhD, Assistant Professor of Radiology, Memorial Sloan Kettering Cancer Center; and Gary A. Ulaner, MD, PhD, Associate Professor of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center. This letter recommends PET/CT to monitor disease progression rather than specifying it as optional and including embolotherapies for treatment of refractory hepatic metastasis.
NCCN Cancer-Associated Venous Thromboembolic Disease Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Guidelines Panel for Cancer-Associated Venous Thromboembolic Disease. Submitted by Sirish A. Kishore MD, Clinical Assistant Professor of Radiology (Affiliated), Stanford University; Adie Friedman MD, Assistant Professor of Radiology, Mount Sinai Medical Center; and Deepak Sudheendra MD, Assistant Professor of Clinical Radiology, University of Pennsylvania. This Letter requests five specific changes for inclusion to the guidelines for Cancer-Associated Venous Thromboembolic Disease.
Download the 2020 Letter
NCCN Colorectal Cancer Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Guidelines on Colon and Rectal Cancer. Authored by Bruno C. Odisio, MD, PhD, FSIR (lead author); Kamran Ahrar, MD; Juan Camacho, MD; and Ahmad Parvinian, MD, this letter requests specific changes to the NCCN Colon and Rectal Cancer Guidelines, including the acknowledgment of recent data demonstrating the improved outcomes of thermal ablation over surgery for select patients with small colorectal cancer liver metastases; clarification of the distinction between image-guided thermal ablation and other local therapies such as SBRT; and the creation of a specific “Principles of Locoregional Therapy” section. Additionally, the letter requests an increased number of interventional radiologists (IRs) on the panel.
NCCN Hepatobiliary Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Guidelines of Hepatobiliary. Submitted by Gregory Nadolski, MD, Assistant Professor, University of Pennsylvania; Sid Padia, MD, Associate Professor, UCLA; Amanda Smolock, MD, PhD; and Beau Toskich, MD, Radiologist, Mayo Clinic. This letter requests the NCCN Guidelines Panel for Hepatobiliary Cancer review five specific changes and data regarding the treatment of HCC.
NCCN Kidney Cancer Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Renal Guidelines. Submitted by Ronald S. Arellano, MD, Professor of Radiology, Harvard Medical School, Massachusetts General Hospital; Thomas D. Atwell MD, Professor of Radiology, Mayo Clinic; and S. William Stavropoulos MD, Professor of Radiology, University of Pennsylvania. This letter requests the NCCN Kidney Cancer Guideline Panel review four specific changes, including the inclusion of microwave ablation as a thermal ablation option, revise the recommendations for imaging follow-up after thermal ablation, and include thermal ablation as a treatment option in the management of T1b tumors.
NCCN Lung Cancer Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Non-Small Cell Lung Guidelines. Authored by Aaron W.P. Maxwell, MD; Patrick W. Eiken, MD; Robert D. Suh, MD, this letter requests six specific changes to the NCCN Non-Small Cell Lung Guidelines panel centering on the incorporation of image-guided thermal ablation into the main treatment algorithm for patients with primary and metastatic NSCLC.
NCCN Neuroendocrine and Adrenal Tumors Guidelines
The Society of Interventional Oncology has submitted updates to the NCCN Guidelines of Neuroendocrine and Adrenal Tumors. Authored by Rony Avritscher, MD; Nicholas Fidelman, MD; Sarah White, MD, MS, FSIR; and Etay Ziv, MD, PhD, this letter requests the NCCN Neuroendocrine and Adrenal Tumors Guidelines be updated to consider the addition of liver-directed therapy (selective internal radiation therapy, chemoembolization, embolization, ablation, SBRT).
NCCN Neuroendocrine Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Guidelines for Neuroendocrine. Submitted by Etay Ziv, MD, PhD, Memorial Sloan Kettering Cancer Center; Nicholas Fidelman, MD, University of California San Francisco; and Rony Avritscher, MD, UT MD Anderson Cancer Center. This letter requests the NCCN Neuroendocrine and Adrenal Tumors Guideline Panel review data regarding seven specific changes to update the role of liver-directed therapies (LDT) in the clinical practice guidelines in oncology.
NCCN Pancreatic Adenocarcinoma Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Pancreatic Adenocarcinoma Guidelines. Authored by Hooman Yarmohammadi, MD; Govindarajan Narayanan, MD; F. Edward Boas, MD PhD; Vlasios Sotirchos, MD; and Peiman Habibollahi, MD, this letter requests three specific changes to the NCCN Pancreatic Adenocarcinoma Guidelines panel centering on the incorporation of locoregional therapies for patients with locally advanced pancreatic cancer, as a palliative or supportive care option in patients with advanced disease, and therapy for patients with metastatic cancer.
Download the 2023 Letter
Download the 2022 Letter
NCCN Palliative Care Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Palliative Care Guidelines. Submitted by Theodore L. Vander Velde, MD, Institute of Radiology Washington University School of Medicine (lead author); Stephen J. Hunt, MTR, MD, PhD, FSIR, University of Pennsylvania; Jack Jennings, MD, PhD, FSIR, Washington University St. Louis; Brandon Key, MD, Medical College of Wisconsin; Gina Landinez, MD, Baptist Health South Florida; Neil Resnick, MD, FSIR, Emory Saint Joseph’s Hospital; Anthony Tadros, MD, UC San Diego Health; and Sean Tutton, MD, FSIR, FCIRSE, UC San Diego Health. This letter requests the NCCN Palliative Care Guidelines Panel review the six submitted recommendations seeking further inclusion of Interventional Oncology into the multidisciplinary palliative care team, specifically promoting palliative tumor ablation and augmentation as well as neural ablation for refractory pain. Additionally, the letter requests that the NCCN Palliative Care Panel consider including an interventional radiologist (IR) on the panel.
NCCN Prostate Cancer Guidelines
The Society of Interventional Oncology submitted updates to the NCCN Prostate Cancer Guidelines. Submitted by David A. Woodrum, MD, PhD, Associate Professor of Radiology and Urology, Mayo Clinic; Vijay Ramalingam, MD, Assistant Professor of Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School; Eric Walser, MD, Professor and Chair of Radiology, UTMB; and Lance Mynderse, MD, MS, Associate Professor of Urology and Radiology, Mayo Clinic, this letter requests the NCCN Prostate Cancer Guidelines Panel review the recommendations for inclusion of focused ultrasound ablation, cryoablation, and laser ablation as initial treatment options for very low risk, low risk, and favorable intermediate-risk groups.
Download the 2025 Letter
Download the 2024 Letter
Download the 2023 Letter